Search found 12 matches

by isegarra
Thu Apr 27, 2017 3:40 am
Forum: How Do I...?
Topic: PMstep function
Replies: 0
Views: 282

PMstep function

Dear all, I need some input regarding the way PMstep function works and how to interpret its output. In essence, this function will identify possible differences due to the covariates (e.g. sex, weight, a condition, etc). If we have only one covariate the result may be interpreted straight forwardly...
by isegarra
Tue Sep 29, 2015 3:28 am
Forum: How Do I...?
Topic: repetitive "Subject 1 is Singular" error.
Replies: 0
Views: 781

repetitive "Subject 1 is Singular" error.

Hi all, I am running the IT2B engine (Pmetrics vesion 1.4.1 on a win7, 32 bits system) and got the error below at cycle 10. If I limit the cycles to 9, then it is ok but does not converge: ERROR REPORT THE CURRENT ESTIMATE OF THE COVARIANCE MATRIX OF THE PARAMETER ESTIMATES FOR SUBJECT 1 IS "SINGULA...
by isegarra
Wed Jul 29, 2015 11:59 am
Forum: Installation
Topic: CHMAX*.*
Replies: 1
Views: 776

CHMAX*.*

Hi all!

I installed version 1.4.1 and started it. Eventually I got it to start running and got the following line before starting the iteration in NPAG engine:

cannot find ...\....directory.... Runs\CHMAX*.* and then stops.

Running Win7, 64bit.

Any idea?

Thanks

Ignacio
by isegarra
Thu Jul 23, 2015 12:18 pm
Forum: Bug Reporting
Topic: np_run.exe is not a Win32 application
Replies: 4
Views: 934

np_run.exe is not a Win32 application

I keep getting this error

np_run.exe is not a Win32 application

I´m running in a win7, 64 bit and the model has differential equations. It also happens in a Win7, 32 bit version. Any idea why it is happening?

Thanks

Ignacio
by isegarra
Fri Jul 10, 2015 8:09 am
Forum: How Do I...?
Topic: Adding the tissue weight for each mouse
Replies: 3
Views: 950

Re: Adding the tissue weight for each mouse

Hi Gellert, Nice seeing you here. Yeah, Limoges was great!! Thanks for your feedback. Actually, I have not entered the tissue weight yet as I was not sure how to arrange them. And being busy with end of semester issues... I think it probably makes more sense to arrange them as you suggest, as an ind...
by isegarra
Tue Jun 09, 2015 3:12 am
Forum: How Do I...?
Topic: Adding the tissue weight for each mouse
Replies: 3
Views: 950

Adding the tissue weight for each mouse

Hi all: I have a question regarding the configuration of the data file. I am trying to enter the weight of the different organs for which I have a measured concentration (OUTput eq 1, 2, 3, 4) as well as the weight of the mouse. I wonder is the cov arrangement is correct as the table shows (WT colum...
by isegarra
Fri May 22, 2015 3:37 am
Forum: How Do I...?
Topic: How to add trend line in a covariate plot?
Replies: 3
Views: 1158

Re: How to add trend line in a covariate plot?

Thanks for your reply! I looked at the lower part of the plot, plot(cov.1, Ka~age, lowess=T, reg=F, ylim=c(0,0.8)) and you were correct... So I think this solves the initial question. Low2.jpeg I also tried the loess function but did not seem to work properly. I guess some descriptor is not correct,...
by isegarra
Thu May 21, 2015 11:20 am
Forum: How Do I...?
Topic: How to add trend line in a covariate plot?
Replies: 3
Views: 1158

How to add trend line in a covariate plot?

Hi all: I am trying to plot the effect of a covariate (weight) on a PK parameter (Ka). For this I can use plot(cov.1, Ka~wt) and add a regression line afterwards, plot(cov.1, Ka~wt, reg=T) . Then I get: Reg1.jpeg However, I would like to add a trend line or moving average instead of the linear regre...
by isegarra
Thu Feb 19, 2015 1:05 pm
Forum: How Do I...?
Topic: Interpretation of Marginal Plots
Replies: 2
Views: 1656

Re: Interpretation of Marginal Plots

Thanks Michael.

Yes I have that number of subjects.
I attach a final graph as example. An observation seems to me also that is also that the wider the range it seems that there will be more dispersion of the value.

Thanks again.

Ignacio
by isegarra
Thu Feb 19, 2015 2:16 am
Forum: How Do I...?
Topic: Interpretation of Marginal Plots
Replies: 2
Views: 1656

Interpretation of Marginal Plots

Hi all, I have several questions.... - I got some unusual marginal plot where all red bars seem to have the same associated p-value (0.029, from the support points table). Usually, I get the with different "height". Any reason for this behavior? - There are some constants close to upper limit or eve...