Search found 43 matches

by pharmpk
Tue Dec 17, 2019 9:58 am
Forum: Installation
Topic: Macintosh 10.15.1 Catalina Problem
Replies: 2
Views: 149

Re: Macintosh 10.15.1 Catalina Problem

Mac Catalina 10.15.2 seems to have helped with one problem. That is, the security issue. Now in System Preferences / Security & Privacy / General it is possible to allow Pmetrics.so without it being signed. In 10.15.1 this allowance seemed to be ignored. I had another problem before resolution but i...
by pharmpk
Fri Dec 06, 2019 12:22 pm
Forum: Installation
Topic: Macintosh 10.15.1 Catalina Problem
Replies: 2
Views: 149

Macintosh 10.15.1 Catalina Problem

Hi I started up R-Studio/PMetrics this morning after a little while using it and got a message “Pmetrics.so” cannot be opened because the developer cannot be verified. Could this be due to Catalina's new security requirements? --- Message in R Studio Console Error: package or namespace load failed f...
by pharmpk
Mon May 20, 2019 10:17 am
Forum: How Do I...?
Topic: Missing covariate values
Replies: 4
Views: 578

Re: Missing covariate values

Thanks for the suggestions. However, I already have two metabolites in the model and 10-12 covariates with only 1- 4 entries per subject. I think after considering wt, age, type covariates for inclusion in the model I'll look at the DDI 'covariates' post Pmetric analysis.
by pharmpk
Fri May 17, 2019 9:22 am
Forum: How Do I...?
Topic: Missing covariate values
Replies: 4
Views: 578

Missing covariate values

I'm trying to use covariates as a way of including drug interactions on the primary drug parameters. However, not all subjects receive the same potentially interfering drugs. Thus, there are many missing entries for the secondary drug exposure. Entering 0.0 allows the analysis to proceed as does -99...
by pharmpk
Thu May 09, 2019 12:30 pm
Forum: How Do I...?
Topic: Error npagdriv.f - no such file
Replies: 4
Views: 458

Re: Error npagdriv.f - no such file

Oh dear. It looks like I had some extra empty columns in the .csv file. I had them in my overall spreadsheet for extra covariates and exported the data as the .csv file for Pmetrics. Deleting the unnecessary, empty columns seems to have fix the 'problem'.
by pharmpk
Wed May 08, 2019 1:00 pm
Forum: How Do I...?
Topic: Error npagdriv.f - no such file
Replies: 4
Views: 458

Re: Error npagdriv.f - no such file

Hmm. I've got three test runs working. Drug, Drug and one metabolite and Drug with two metabolites. Randomly generated data. Some zero and < zero data points so the error "Observations <= 0 omitted from log plot." This can be fixed. Also "ties should not be present for the Kolmogorov-Smirnov test" -...
by pharmpk
Tue May 07, 2019 10:28 am
Forum: How Do I...?
Topic: Error npagdriv.f - no such file
Replies: 4
Views: 458

Re: Error npagdriv.f - no such file

Hi Michael Thanks for the reply. I don't an error... ;-) At little more info. From the terminal window At line 6501 of file NPprep_120.f (unit = 57, file = '/var/folders/30/mv1n8y1j4_56ps41p_wgznfm0000gn/T/gfortrantmpOMhxsK') Fortran runtime error: End of file Error termination. Backtrace: #0 0x1547...
by pharmpk
Mon May 06, 2019 1:19 pm
Forum: How Do I...?
Topic: Error npagdriv.f - no such file
Replies: 4
Views: 458

Error npagdriv.f - no such file

I'm running a model expressed as ODEs for the first time and I'm getting an error gfortran: error: npagdriv.f: No such file or directory I've been running algebraic models OK. I added a #Diff section to the model following the examples given #Dif XP(1) = -Ka*X(1) XP(2) = Ka*X(1) - K20*X(2) XP(3) = X...
by pharmpk
Mon Mar 04, 2019 1:49 pm
Forum: How Do I...?
Topic: Comparing models
Replies: 3
Views: 606

Re: Comparing models

You can have different number of parameters for different models but the error functions should be the same.

There are various criteria for choosing the 'best' model. Residual plots, AIC, -2*LL, parameter cv, etc. Sometimes they all point in the same direction.
by pharmpk
Fri Feb 08, 2019 2:01 pm
Forum: Installation
Topic: NPDE installation
Replies: 4
Views: 909

Re: NPDE installation

I was able to download version 2.0 from CRAN archive: https://cran.r-project.org/src/contrib/Archive/npde/ I installed (RStudio) using the Install Package... using > install.packages("~/Downloads/npde_2.0.tar.gz", repos = NULL, type = "source") after an error message looking for mclust I install tha...