Search found 229 matches

by mneely
Sun Feb 02, 2020 7:36 am
Forum: Installation
Topic: PMetrics on Catalina
Replies: 2
Views: 1411

Re: PMetrics on Catalina

This is a permissions issue on Catalina and we are working on a permanent fix. In the meantime, please open a Terminal in your computer (Launchpad -> Other -> Terminal) and run the following command. You can copy this text and paste it into Terminal. install_name_tool -change /Library/Frameworks/R.f...
by mneely
Sat Dec 07, 2019 1:03 am
Forum: Installation
Topic: Macintosh 10.15.1 Catalina Problem
Replies: 2
Views: 1138

Re: Macintosh 10.15.1 Catalina Problem

Nothing in Catalina a priori breaks the installation, as I’m running it on Catalina myself. I don’t recall seeing that error message at any time after I upgraded to Catalina. Perhaps rebuilding your installation will help this? 1) I have discovered that you can have command line tools without the hu...
by mneely
Wed May 22, 2019 9:11 am
Forum: How Do I...?
Topic: Missing covariate values
Replies: 4
Views: 2092

Re: Missing covariate values

PMstep() will do a linear regression backwards elimination (could do forward/backward) of all covariates vs. all parameters and report the P values for regression coefficients based on retention in the linear model. It uses AIC to discard or retain covariates. PMstep is based on the R "step" functio...
by mneely
Fri May 17, 2019 10:35 am
Forum: How Do I...?
Topic: Missing covariate values
Replies: 4
Views: 2092

Re: Missing covariate values

If you have multiple interacting drugs possible and you want to model all of them, then set a covariate to 0 or 1 for each drug and use an exponential model. #PRI Ke0,0,5 mod1,-1,1 mod2,-1,1 mod3,-1,1 mod4,-1,1 ... #COV INT1 INT2 INT3 INT4 ... #SEC Ke = Ke0 * exp(mod1*INT1 + mod2*INT2 + mod3*INT3 + ...
by mneely
Fri May 17, 2019 10:29 am
Forum: How Do I...?
Topic: Missing covariate values
Replies: 4
Views: 2092

Re: Missing covariate values

You could do something like INT = 0 or 1 as a covariate for receipt of an interacting drug and then have your model do this: #PRI Ke1,0,5 Ke2,0,5 ... #COV INT #SEC Ke = Ke1*(1-INT) + Ke2*INT This will set Ke = Ke1 when INT=0 (no interacting drug) and Ke = Ke2 when INT=1 (interacting drug present). D...
by mneely
Mon May 06, 2019 2:15 pm
Forum: How Do I...?
Topic: Error when include many variables
Replies: 3
Views: 1562

Re: Error when include many variables

My first question was whether you had been able to run a simpler model, even one from the examples available on our website. Just want to make sure you have a working installation.
by mneely
Mon May 06, 2019 2:13 pm
Forum: How Do I...?
Topic: Three comp model
Replies: 1
Views: 1098

Re: Three comp model

I don't see an error with your output block. Can you run it anyway without PMcheck? NPrun(...,nocheck=T) will suppress PMcheck.
by mneely
Mon May 06, 2019 2:10 pm
Forum: How Do I...?
Topic: Error npagdriv.f - no such file
Replies: 4
Views: 1893

Re: Error npagdriv.f - no such file

Hi David, Something isn't allowing the run to start, which is why there isn't an npagdriv.f file. If you look at the DOS/Terminal window before closing it, there might be an error message embedded there. I don't see any errors in your #DIFF block, so it is likely elsewhere. Do you have definitions f...
by mneely
Wed Apr 17, 2019 10:23 am
Forum: How Do I...?
Topic: Error when include many variables
Replies: 3
Views: 1562

Re: Error when include many variables

Two things: 1) Did it ever run as a simpler model? 2) Make sure you define the purpose for your model. If you want to simulate, say for a PTA, and you truly believe that all those covariates are related to your model parameters, then it makes sense to include them all. However, you will likely be fi...
by mneely
Fri Apr 05, 2019 9:42 am
Forum: How Do I...?
Topic: Compiler
Replies: 1
Views: 1079

Re: Compiler

You should be able to type "1" and press <Return>.